Genetic Manipulation

Should men have the right to have their cells manipulated so they can become biological mothers? Should women past child-bearing age have the same right if their own eggs are no longer viable? More to the point, should we all have the right to do whatever it takes to have a baby if that is our desire and also, to obtain the baby we want?

These questions have ceased to be grist for science fiction authors. Researchers recently announced that they have genetically manipulated human skin cells to become eggs, including those of men (the idea being to eventually enable both members of a same sex couple to have a genetic connection with their child). Then, after more genetic tinkering, the eggs were fertilized into embryos via IVF. Finally, the biotechnologists monitored embryonic development until the experiment was stopped, and the embryos destroyed.

No pregnancy has been established with this technique. But that is cold comfort. The researchers plan to keep experimenting and I have little doubt that when they overcome remaining technical difficulties, someone will create a pregnancy using “skin cell” embryos. After all, what beyond self-restraint—currently in little supply in this field—is to stop them?

Resources are being invested at an astounding level in radical reproductive technologies. Now, researchers have created human eggs from skin cells and successfully fertilized some of them with IVF. From the Guardian story: Researchers have created human eggs from skin cells, potentially transforming IVF treatment for couples who have no other options. The work is at an early stage but if scientists can perfect the process it would provide genetically related eggs for women who are infertile because of older age, illness or medical treatment. The same procedure could be used to make eggs for same-sex male couples. The effort involved a cloning-like technique: The Oregon team took a similar approach by collecting skin cells from women and removing the Read More ›

Scientists in China have previously successfully manufactured mice with two mothers and no father. Now, they have genetically manipulated sperm from two male mice to allow both to father pups. From the New Scientist story: For the first time, mice with two fathers have gone on to have offspring of their own — marking a significant step towards enabling two men to have children to whom they are both genetically related. However, there is still a long way to go before this could be attempted in people. Yanchang Wei at Shanghai Jiao Tong University in China achieved the feat by putting two sperm cells together in an egg whose nucleus had been removed. The team then used a method called Read More ›

The media are such suckers for hyperbolic biotech stories. Colossal Laboratories and Bioscience made headlines for supposedly having genetically engineered a return of dire wolves that disappeared about 12,500 or so years ago, which many stories claimed to now be “de-extinct” after three gene-edited pups were born. Uh, no. The company actually engineered gray wolves to have white fur and (if it works) a larger stature. But despite a similar appearance, gray wolves are not actually close relatives of the extinct species. From the New Scientist story: Grey wolves and dire wolves were thought to be very closely related based on their physical similarities but a 2021 study of ancient DNA revealed that they last shared a common ancestor around Read More ›