CRISPR

Should men have the right to have their cells manipulated so they can become biological mothers? Should women past child-bearing age have the same right if their own eggs are no longer viable? More to the point, should we all have the right to do whatever it takes to have a baby if that is our desire and also, to obtain the baby we want?

These questions have ceased to be grist for science fiction authors. Researchers recently announced that they have genetically manipulated human skin cells to become eggs, including those of men (the idea being to eventually enable both members of a same sex couple to have a genetic connection with their child). Then, after more genetic tinkering, the eggs were fertilized into embryos via IVF. Finally, the biotechnologists monitored embryonic development until the experiment was stopped, and the embryos destroyed.

No pregnancy has been established with this technique. But that is cold comfort. The researchers plan to keep experimenting and I have little doubt that when they overcome remaining technical difficulties, someone will create a pregnancy using “skin cell” embryos. After all, what beyond self-restraint—currently in little supply in this field—is to stop them?

Biotechnology is like Star Wars’, “Force”: It has a dark side and a light side. CRISPR, the gene-editing technique that can alter any cell and life-form on the planet, exemplifies the point. It can be deployed to alter a bird flu virus to kill multitudes. It can be used for eugenics manipulations. And, in theory, it can save the lives of people afflicted with genetic diseases. That seems to have just happened. Baby KJ’s life was apparently saved or extended — at least for now — using the technique to treat a genetically caused liver condition. From the Stat story: For the first time, scientists say they have reached into the genome of a severely ill child and rewritten the Read More ›